For the first-time visitor, Rome belongs at or near the top of your list. This city is a wonderful blend of historical sites, charming piazzas and neighborhoods, world-class museums, and iconic sites. The history here spans 28 centuries, making Rome one of the oldest inhabited cites in Europe (and one of the best places to visit in Italy). Just hearing the name conjures up some of the most famous landmarks in the world…the Colosseum, the Sistine Chapel, and the Vatican. Best Places in Italy: Itinerary Suggestions.